- 询价
- Miltenyi Biotec
- 德国
- 130-099-282
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Syk
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA111
- 标记物：
APC
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:10
- 抗体英文名：
Syk Antibody, anti-human, REAfinity™
- 抗体名：
Syk Antibody, anti-human, REAfinity™
- 规格：
100 tests in 1 mL
Identification and enumeration of Syk+ cells by flow cytometryClone REA111 recognizes Syk, a 72 kDa non-receptor tyrosine kinase cytoplasmic protein. Syk belongs to the SYK/ZAP 70 family of tyrosine protein kinases and is mainly expressed in hematopoietic cells. Activated immunoreceptors, phosphorylated at ITAM motifs recruit Syk from the cytoplasm to the signalosome complex at the perimembrane location. Syk, upon binding of SH2 domains to immunoreceptor ITAM, is activated and undergoes autophosphorylation and phosphorylation by SRC kinases. Activated Syk catalyzes tyrosine phosphorylation of multiple downstream proteins which regulate signaling pathways such AKT, MAP kinase, and NF-κB. A wide variety of cellular and physiological functions such as cell activation and differentiation are regulated by Syk. | Additional information: Clone REA111 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Kurosaki, T. et al. (1995) Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182 (6): 1815–1823. | Sada, K. et al. (2001) Structure and function of Syk protein-tyrosine kinase. J. Biochem. 130: 177–186. | Siraganian, R. P. et al. (2002) Protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol. 38 (16-18): 1229–1233.
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Syk Antibody, anti-human, APC, REAfinity™, 100 tests in 1 mL
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