- 询价
- Miltenyi Biotec
- 德国
- 130-104-135
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
TCL1
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA289
- 标记物：
PE-Vio 770
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:10
- 抗体英文名：
TCL1 Antibody, anti-human, REAfinity™
- 抗体名：
TCL1 Antibody, anti-human, REAfinity™
- 规格：
30 tests in 300 µL
Identification and enumeration of TCL1+ cells by flow cytometryClone REA289 recognizes the T cell leukemia/lymphoma protein, a 14 kDa symmetrical b-barrel structure protein also known as oncogene TCL-1 or protein p14 TCL1. The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T cell receptor loci in human T cell leukemias and lymphomas. In the lymphoid compartment, TCL1 expression is limited to CD4-CD8-CD3- thymocytes, CD34+CD19+ pro–B cell through IgM-negative pre–B cells, as well as plasmacytoid subset of dendritic cells. The members of the TCL1 proto-oncogene family (TCL1, MTCP1, and TCL1b) bind to Akt1, increasing its phosphorylation status and kinase activity. Further, TCL1 is able to promote the formation of oligomeric TCL1-Akt protein complexes in which the kinase is preferentially phosphorylated and activated. | Additional information: Clone REA289 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Virgilio, L. et al. (1994) Identification of the TCL1 gene involved in T-cell malignancies. Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12530–12534. | Laine, J. et al. (2002) Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. J. Biol. Chem. 277 (5): 3743–3751. | Laine, J. et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 (2): 395–407.
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TCL1 Antibody, anti-human, PE-Vio® 770, REAfinity™, 30 tests in 300 µL
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