- 询价
- Miltenyi Biotec
- 德国
- 130-130-900
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Slug
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA404
- 标记物：
Vio B515
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
Slug Antibody, anti-human, REAfinity™
- 抗体名：
Slug Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of slug+ cells by flow cytometryClone REA404 recognizes the human slug antigen, a zinc finger transcriptional repressor also known as SNAI2. Slug is an inducer of the epithelial to mesenchymal transition (EMT) which is a highly conserved developmental program activated during mesoderm formation and neural crest development. This program also promotes dissemination of single malignant cells from primary epithelial tumors. During EMT, cells discard their epithelial characteristics, including cell adhesion and polarity, reorganize their cytoskeleton and acquire a mesenchymal morphology and the ability to migrate. One of the hallmarks of EMT is the functional loss of the cell-cell junction protein E-cadherin. Several transcription factors including slug have been identified to repress E-cadherin expression, which plays important roles in cell adhesion and in the maintenance of tissue structure. These EMT transcription factors bind to E-box elements in the promoter region of E-cadherin leading to transcriptional repression of junctional complexes and induction of the mesenchymal phenotype. | Additional information: Clone REA404 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Guo, W. et al. (2012) Slug and Sox9 cooperatively determine the mammary stem cell state. Cell 148 (5): 1015–1028. | Hemavathy, K. et al. (2000) Human Slug is a repressor that localizes to sites of active transcription. Mol. Cell. Biol. 20 (14): 5087–5095. | Sánchez-Martín, M. et al. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum. Mol. Genet. 11 (25): 3231–3236.
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Slug Antibody, anti-human, Vio® B515, REAfinity™, 100 tests in 200 µL
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