- 询价
- Miltenyi Biotec
- 德国
- 130-107-966
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
QA-2
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA523
- 标记物：
Biotin
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 抗体英文名：
QA-2 Antibody, anti-mouse, REAfinity™
- 抗体名：
QA-2 Antibody, anti-mouse, REAfinity™
- 规格：
9 µg in 300 µL
Identification and enumeration of QA-2+ cells by flow cytometryClone REA523 recognizes the mouse Qa-2 antigen, a 40 kDa single-pass type I membrane protein, which is also known as H-2 class I histocompatibility antigen Q7 alpha chain (H2-Q7). Qa-2 is a murine non-classical MHC class I molecule involved in the modulation of immune responses by interacting with T CD8+ and NK cell inhibitory receptors. The murine Qa-2 genes map to the H-2Q region, between the classical class I H-2D locus and the H-2TL cluster of class lb sequences. This locus encodes a variable number of class Ib genes in different strains. Strains expressing high (Qa-2high), medium (Qa-2med), low (Qa-2low), and no Qa-2 (Qa-2nul) were identified. Qa-2 is found as membrane-bound and soluble isoforms generated by alternative splicing. It is expressed mostly by lymphoid-derived cells and plays an important role in controlling growth and murine fetal development and, like HLA-G, the molecule is related to the protection of the fetus by inhibiting maternal NK cell-mediated lysis. | Additional information: Clone REA523 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Melo-Lima, B. L. et al. (2014) Differential transcript profiles of MHC class Ib(Qa-1, Qa-2, and Qa-10) and Aire genes during the ontogeny of thymus and other tissues. J Immunol: . | Devlin, J. J. et al. (1985) Duplicated gene pairs and alleles of class I genes in the Qa2 region of the murine major histocompatibility complex: a comparison. EMBO J. 4 (12): 3203–3207. | Lu, N. et al. (2011) Dynamic expression of Qa-2 during acute graft rejection. Mol. Med. 17 (3-4): 248–255.
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QA-2 Antibody, anti-mouse, Biotin, REAfinity™, 9 µg in 300 µL
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