- 询价
- Miltenyi Biotec
- 德国
- 130-123-018
- 2025年12月09日
- Flow cytometry
- human cell line
- human, non-human primate
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Notch2
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA1204
- 标记物：
Vio Bright B515
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
Notch2 Antibody, anti-human, REAfinity™
- 抗体名：
Notch2 Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of Notch2+ cells by flow cytometryClone REA1204 recognizes human Notch2, a member of the Notch receptor family. Upon binding its membrane-bound ligand of the Delta-like or Jagged family members (Jagged1, Jagged2, and Delta1), the Notch receptor undergoes two proteolytic cleavage steps eventually releasing the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, where it activates transcription within a multiprotein complex. The Notch signaling is essential for the physiologic development of natural killer (NK) cells. Notch2 is expressed on various hematopetic cells, including T cell precursors in the thymus and activated peripheral T cells. In addition, the altered expression of Notch2 in various leukemias, lymphomas, and cancers has been reported. | Additional information: Clone REA1204 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Haraguchi, K. et al. (2009) Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15. J Immunol 182 (10): 6168–6178. | Gray, G. E. et al. (1999) Human ligands of the Notch receptor. Am. J. Pathol. 154 (3): 785–794.
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Notch2 Antibody, anti-human, Vio® Bright B515, REAfinity™, 30 tests in 60 µL
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