- 询价
- Miltenyi Biotec
- 德国
- 130-115-413
- 2025年12月09日
- Intracellular flow cytometry
- human cell line
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Mcl-1 pS159
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA924
- 标记物：
PE
- 适应物种：
human, mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry
- 浓度：
1:50
- 抗体英文名：
Mcl-1 pS159 Antibody, anti-human/mouse, REAfinity™
- 抗体名：
Mcl-1 pS159 Antibody, anti-human/mouse, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of Mcl-1 pS159+ cells by flow cytometryClone REA924 recognizes the human and mouse protein Mcl-1 phosphorylated at serine 159 (pS159). Myeloid cell leukemia-1 (Mcl-1), also known as BCL2L3, is a member of the Bcl-2 family of regulator proteins, which play an important role in the regulation of apoptosis. The two isoforms of Mcl-1 regulate cell survival and apoptosis by inhibiting apoptosis and promotion of apoptosis and death-inducing. Mcl-1 is primarily found in the outer membrane of mitochondria and mainly expressed in programmed myeloid cell differentiation. | Additional information: Clone REA924 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Kozopas, K. M. et al. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. U.S.A. 90 (8): 3516–3520. | Chao, J. R. et al. (1998) mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol. 18 (8): 4883–4898. | Bingle, C. D. et al. (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J. Biol. Chem. 275 (29): 22136–22146. | Maurer, U. et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21 (6): 749–760.
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Mcl-1 pS159 Antibody, anti-human/mouse, PE, REAfinity™, 30 tests in 60 µL
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