- 询价
- Miltenyi Biotec
- 德国
- 130-117-071
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
企业认证
相关产品推荐更多 >
CD86 Antibody, anti-rat, Vio® Bright FITC, 30 µg in 1 mL
询价
CD137L (4-1BBL) Antibody, anti-human, Vio® B515, REAfinity™, 30 tests in 60 µL
询价
CD366 (TIM-3) Antibody, anti-human, PE, REAlease®, 100 tests in 200 µL
询价
CD182 (CXCR2) Antibody, anti-mouse, APC-Vio® 770, REAfinity™, 30 µg in 200 µL
询价CD326 (EpCAM) Antibody, anti-human, Vio® Bright B515, REAfinity™, 100 tests in 200 µL
询价
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Ly-49A
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA1018
- 标记物：
APC
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
Ly-49A Antibody, anti-mouse, REAfinity™
- 抗体名：
Ly-49A Antibody, anti-mouse, REAfinity™
- 规格：
150 µg in 1 mL
Identification and enumeration of Ly-49A+ cells by flow cytometry.Clone REA1018 recognizes th mouse Ly-49A antigen, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk, and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells. | Additional information: Clone REA1018 displays negligible binding to Fc receptors.
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验该产品被引用文献
Daws, M. R. et al. (1999) H-2Dd engagement of Ly49A leads directly to Ly49A phosphorylation and recruitment of SHP1. Immunology 97 (4): 656–664. | Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J Immunol 165: 6922–6932. | Zimmer, J. et al. (2001) H-2D ligand expression by Ly49A+ natural killer (NK) cells precludes ligand uptake from environmental cells: Implications for NK cell function. J. Exp. Med. 194 (10): 1531–1539.
技术资料暂无技术资料 索取技术资料
文献支持
Ly-49A Antibody, anti-mouse, APC, REAfinity™, 150 µg in 1 mL
询价
