- 询价
- Miltenyi Biotec
- 德国
- 130-100-064
- 2025年12月09日
- Intracellular flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
LAT pY226
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA146
- 标记物：
PE
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry
- 浓度：
1:11
- 抗体英文名：
LAT pY226 Antibody, anti-human, REAfinity™
- 抗体名：
LAT pY226 Antibody, anti-human, REAfinity™
- 规格：
30 tests in 300 µL
Identification and enumeration of LAT pY226+ cells by flow cytometryClone REA146 recognizes LAT phosphorylated at tyrosine 226. Linker of T cell activation (LAT), a transmembrane adaptor molecule, is constitutively localized in the lipid rafts and is involved in transducing the signal initiated by triggered T cell receptor (TCR). Upon TCR engagement, SRC and SYK family of protein tyrosine kinases (PTKs) are activated and LAT is phosphorylated at multiple conserved tyrosine residues in its cytosolic domain by Syk-family PTK Zap-70. Phosphorylated LAT can associate with several downstream SH2 domain containing proteins such as GRB2, PLCy1, ITK, GADS, and p85 subunit of PI3K to propagate the TCR activation signal and to activate several downstream pathways. pY226 motif can be bound directly by GRB2, GADS, and PLC-y1. Expression of LAT is found in thymocytes, T cells, mast cells, natural killer (NK cells), and platelets. Thymocytes lacking LAT are completely blocked at the pro-T3 stage in thymopoiesis. | Additional information: Clone REA146 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Finco, T. S. et al. (1998) LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 9 (5): 617–626. | Zhang, W. et al. (1999) Essential role of LAT in T cell development. Immunity 10 (3): 323–332. | Zhang, W. et al. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92 (1): 83–92.
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LAT pY226 Antibody, anti-human, PE, REAfinity™, 30 tests in 300 µL
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