- 询价
- Miltenyi Biotec
- 德国
- 130-125-236
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
IRF-8
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA516
- 标记物：
APC
- 适应物种：
human, mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
IRF-8 Antibody, anti-human/mouse, REAfinity™
- 抗体名：
IRF-8 Antibody, anti-human/mouse, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of IRF-8+ cells by flow cytometryClone REA516 recognizes the human and mouse interferon regulatory factor 8 (IRF-8) antigen, a 50 kDa transcription factor, which is also known as interferon consensus sequence–binding protein (ICSBP). IRF-8 belongs to the family of interferon regulatory transcription factors, which consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain with a unique tryptophan pentad repeat. IRF-8 is expressed at very high levels in mononuclear phagocytes, and regulates granulocyte/macrophage differentiation and dendritic cell (DC) development. Acting in heterodimeric complexes with other transcription factors, IRF-8 also controls the transcriptional response of mature myeloid cells to interferons and Toll-like receptor agonists, a response in which IRF-8 binds and transactivates the promotors of IL12B and NOS2. IRF-8 knockout mice display a loss of CD8a+ lymphoid DCs, CD103+ tissue myeloid DCs, and plasmacytoid DCs. | Additional information: Clone REA516 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Hambleton, S. et al. (2011) IRF8 mutations and human dendritic-cell immunodeficiency. N. Engl. J. Med. 365 (2): 127–138. | Yoshida, Y. et al. (2014) The transcription factor IRF8 activates integrin-mediated TGF-β signaling and promotes neuroinflammation. Immunity 40 (2): 187–198. | Driggers, P. H. et al. (1990) An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3743–3747.
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IRF-8 Antibody, anti-human/mouse, APC, REAfinity™, 30 tests in 60 µL
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