- 询价
- Miltenyi Biotec
- 德国
- 130-104-482
- 2025年12月09日
- Intracellular flow cytometry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
IL-1A
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA288
- 标记物：
APC
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry
- 浓度：
1:10
- 抗体英文名：
IL-1A Antibody, anti-mouse, REAfinity™
- 抗体名：
IL-1A Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 1 mL
Identification and enumeration of IL-1A+ cells by flow cytometryClone REA288 recognizes the precursor, secreted and membrane-associated forms of the mouse interleukin-1α (IL-1α) protein. IL-1α is a unique member in the cytokine family in the sense that the structure of its initially synthesized precursor does not contain a signal peptide fragment. After processing by the removal of N-terminal amino acids by specific proteases, the resulting peptide is called "mature" form. Both the 31kDa precursor form of IL-1α and its 18kDa mature form are biologically active. IL-1α is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor type I (IL-1R1). | Additional information: Clone REA288 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Lomedico, P. T. et al. (1984) Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312 (5993): 458–462. | Ben-Sasson, S. Z. et al. (2009) IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proc. Natl. Acad. Sci. U.S.A. 106: 7119–7124. | Sims, J. E. et al. (2010) The IL-1 family: regulators of immunity. Nat. Rev. Immunol. 10 (2): 89–102.
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IL-1A Antibody, anti-mouse, APC, REAfinity™, 30 µg in 1 mL
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