- 询价
- Miltenyi Biotec
- 德国
- 130-130-429
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
IL-12R β2
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA200
- 标记物：
APC
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
IL-12R β2 Antibody, anti-mouse, REAfinity™
- 抗体名：
IL-12R β2 Antibody, anti-mouse, REAfinity™
- 规格：
30 µg in 200 µL
Identification and enumeration of IL-12R β2+ cells by flow cytometryClone REA200 recognizes the mouse Interleukin-12 receptor subunit beta-2 (IL-12R β2) antigen, a Single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R β1 subunit. While the IL-12R β1 subunit is constitutively expressed, the expression of the IL-12R β2 gene is up-regulated by interferon gamma. IL-12R β2 is expressed by Th1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Th1 differentiation. The IL-12R β2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules. The up-regulation of IL-12R β2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. | Additional information: Clone REA200 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Nishikomori, R. et al. (2002) Activated STAT4 has an essential role in Tʜ1 differentiation and proliferation that is independent of its role in the maintenance of IL-12R beta 2 chain expression and signaling. J Immunol 169 (8): 4388–4398. | Yin, Z. et al. (2000) Dominance of IL-12 over IL-4 in gamma delta T cell differentiation leads to default production of IFN-gamma: failure to down-regulate IL-12 receptor beta 2-chain expression. J Immunol 164 (6): 3056–3064. | Presky, D. H. et al. (1996) A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14002–14007.
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IL-12R β2 Antibody, anti-mouse, APC, REAfinity™, 30 µg in 200 µL
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