- 询价
- Miltenyi Biotec
- 德国
- 130-117-400
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
HLA-E
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA1031
- 标记物：
FITC
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
HLA-E Antibody, anti-human, REAfinity™
- 抗体名：
HLA-E Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of HLA-E+ cells by flow cytometryClone REA1031 recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on natural killer (NK) cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity. | Additional information: Clone REA1031 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Lu, L. et al. (2008) Generation and regulation of CD8+ regulatory T cells. Cell. Mol. Immunol. 5 (6): 401–406. | Jiang, H. et al. (2010) HLA-E-restricted regulatory CD8+ T cells are involved in development and control of human autoimmune type 1 diabetes. J. Clin. Invest. 120 (10): 3641–3650. | Pietra, G. et al. (2010) The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors. J. Biomed. Biotechnol.: 907092.
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HLA-E Antibody, anti-human, FITC, REAfinity™, 100 tests in 200 µL
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