- 询价
- Miltenyi Biotec
- 德国
- 130-123-534
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
HLA-A2
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA517
- 标记物：
VioBlue
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:50
- 抗体英文名：
HLA-A2 Antibody, anti-human, REAfinity™
- 抗体名：
HLA-A2 Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of HLA-A2+ cells by flow cytometryClone REA517 recognizes the class I human leukocyte antigen A2 (HLA-A2). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and a soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. | Additional information: Clone REA517 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Bjorkman, P. J. et al. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329 (6139): 506–512. | Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110 (2): 163–169. | Smith, S. N. et al. (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J. Mol. Biol. 425 (22): 4496–4507.
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HLA-A2 Antibody, anti-human, VioBlue®, REAfinity™, 100 tests in 200 µL
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