- 询价
- Miltenyi Biotec
- 德国
- 130-123-554
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
HLA-B7, B27
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA176
- 标记物：
APC
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
HLA-B7, B27 Antibody, anti-human, REAfinity™
- 抗体名：
HLA-B7, B27 Antibody, anti-human, REAfinity™
- 规格：
100 tests in 200 µL
Identification and enumeration of HLA-B7, B27+ cells by flow cytometryClone REA176 recognizes HLA B7 and B27 class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. HLA-B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. HLA-B27 is known for its strong association with inflammatory spondyloarthropathies. It has been also discovered as a protective factor against some severe viral infections. | Additional information: Clone REA176 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Akram, A. et al. (2014) HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent. J Immunol 192 (12): 5520–5528. | Akram, A. et al. (2013) Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection. Eur. J. Immunol. 43 (12): 3254–3267. | den Uyl, D. et al. (2004) Progression of HIV to AIDS: a protective role for HLA-B27? AIDS Rev. 6 (2): 89–96.
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HLA-B7, B27 Antibody, anti-human, APC, REAfinity™, 100 tests in 200 µL
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