- 询价
- Miltenyi Biotec
- 德国
- 130-105-699
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- human cell line
- human, mouse, rat, other
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Histone H3 pS28
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA379
- 标记物：
FITC
- 适应物种：
human, mouse, rat, other
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:11
- 抗体英文名：
Histone H3 pS28 Antibody, anti-human/mouse, REAfinity™
- 抗体名：
Histone H3 pS28 Antibody, anti-human/mouse, REAfinity™
- 规格：
30 tests in 300 µL
Identification and enumeration of histone H3 pS28+ cells by flow cytometryClone REA379 recognizes the human and mouse histone H3 antigen phosphorylated at serine 28 (pS28). Histone H3 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine. Phosphorylation of histone H3 at pS10 and pS28 is very important for chromosome condensation and segregation during mitosis. The phosphorylation of histone H3 at pS10 appears to be involved in the initiation of chromosome condensation but not the maintenance of it. Although phosphorylation of histone H3 at pS10 is related to chromosome assembly, congregation at the metaphase plate, and segregation, phosphorylation of histone H3 at pS28 occurs in chromosomes predominantly during early mitosis and coincides with the initiation of mitotic chromosome condensation in various mammalian cell lines. | Additional information: Clone REA379 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Wells, D. et al. (1985) Structure of a human histone cDNA: evidence that basally expressed histone genes have intervening sequences and encode polyadenylylated mRNAs. Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2834–2838. | Choi, H. S. et al. (2005) Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase alpha. J. Biol. Chem. 280 (14): 13545–13553. | Dong, Z. et al. (2006) The role of histone H3 phosphorylation (Ser10 and Ser28) in cell growth and cell transformation. Mol. Carcinog. 45 (6): 416–421.
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Histone H3 pS28 Antibody, anti-human/mouse, FITC, REAfinity™, 30 tests in 300 µL
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