- 询价
- Miltenyi Biotec
- 德国
- 130-123-973
- 2025年12月09日
- Intracellular flow cytometry, Mass cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Granzyme A
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA162
- 标记物：
PE
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
Granzyme A Antibody, anti-human, REAfinity™
- 抗体名：
Granzyme A Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of Granzyme A+ cells by flow cytometryClone REA162 recognizes granzyme A, a member of serine protease family expressed exclusively by cytotoxic T lymphocytes and natural killer (NK) cells. Granzyme A is a homodimeric protease and is one of the five granzymes expressed by humans. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells. Granzymes other than granzyme B, exert relatively weaker apoptotic activity. Additional reported functions of granzyme A include, to facilitate the migration of T and NK cells and induction of cytokine secretion. | Additional information: Clone REA162 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Grossman, W. J. et al. (2004) Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104: 2840–2848. | Müllbacher, A. et al. (1999) Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. U.S.A. 96 (13): 13950 –13955. | Trapani, J. A. (2001) Granzymes: a family of lymphocyte granule serine proteases. Genome Biol. 2 (12): 3014.1–3014.7.
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Granzyme A Antibody, anti-human, PE, REAfinity™, 30 tests in 60 µL
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