- 询价
- Miltenyi Biotec
- 德国
- 130-113-036
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
GITRL
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA841
- 标记物：
Biotin
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
GITRL Antibody, anti-human, REAfinity™
- 抗体名：
GITRL Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of GITRL+ cells by flow cytometryClone REA841 recognizes the human GITRL, also known as the ligand for GITR (glucocorticoid-induced TNF receptor superfamily-related protein) and also called AITR (activation-inducible TNF receptor superfamily-related protein). GITRL, a type II membrane protein and a member of the TNF superfamily, is highly expressed in small intestine, ovary, testis, kidney, and endothelial cells. GITRL is not found in resting or stimulated T cells, B cells, or peripheral blood mononuclear cells (PBMCs). After stimulation by bacterial lipopolysaccharides (LPS), GITRL is upregulated. GITR and GITRL might play an important role for interactions between activated T lymphocytes and endothelial cells. Furthermore, overexpression on monocyte-derived DC enhances their capacity to induce antigen-specific T cell responses. | Additional information: Clone REA841 displays negligible binding to Fc receptors.
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文献和实验该产品被引用文献
Kwon, B. et al. (1999) Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. J. Biol. Chem. 274 (10): 6056–6061. | Gurney, A. L. et al. (1999) Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 9: 215–218. | Shevach, E. M. et al. (2006) The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat. Rev. Immunol. 6 (8): 613–618. | Tuyaerts, S. et al. (2007) Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells. J Leukoc Biol 82 (1): 93–105.
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GITRL Antibody, anti-human, Biotin, REAfinity™, 30 tests in 60 µL
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