- 询价
- Miltenyi Biotec
- 德国
- 130-128-690
- 2025年12月09日
- Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- human cell line
- human, mouse
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
GATA3
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA174
- 标记物：
Vio R667
- 适应物种：
human, mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Mass cytometry
- 浓度：
1:50
- 抗体英文名：
GATA3 Antibody, anti-human/mouse, REAfinity™
- 抗体名：
GATA3 Antibody, anti-human/mouse, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of GATA3+ cells by flow cytometryClone REA174 recognizes GATA3, a member of the GATA family of transcription factors. Like other members of the family, GATA3 contain zinc finger motifs involved in recognizing the canonical GATA DNA sequence. GATA3 has two trans-activating domains and two zinc finger domains, each followed by a conserved basic region. Expression of GATA3 is found in developing and mature T cells, natural killer (NK) cells, subset of NKT cells, and endothelial cells. Primary function attributed to GATA3 is to regulate the T helper 2 (Tʜ2) cell differentiation. However, role of GATA3 is also recognized in early T cell commitment and CD4+ T cell development . | Additional information: Clone REA174 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Ho, I. et al. (2007) GATA-3 - not just for Tʜ2 cells anymore. Cell. Mol. Immunol. 4 (1): 15–29. | Zaiss, D. M. et al. (2017) Epidermal growth factor receptor expression licenses type-2 helper T cells to function in a T cell receptor-independent fashion. Immunity 47 (4): 710–722. | Ting, C. N. et al. (1996) Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 284 (6608): 474–478. | Joulin, V. et al. (1991) A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. EMBO J. 10: 1809–1816. | Qian, L. et al. (2014) Alkylglycerols modulate the proliferation and differentiation of non-specific agonist and specific antigen-stimulated splenic lymphocytes. PLoS One 9 (4): e96207. | Martinelli, G. et al. (2018) Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients. J. Transl. Med. 16 (1): 172.
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GATA3 Antibody, anti-human/mouse, Vio® R667, REAfinity™, 30 tests in 60 µL
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