- 询价
- Miltenyi Biotec
- 德国
- 130-127-921
- 2025年12月09日
- Flow cytometry
- human cell line
- human
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
GARP (LRRC32)
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA166
- 标记物：
PE
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 抗体英文名：
GARP (LRRC32) Antibody, anti-human, REAfinity™
- 抗体名：
GARP (LRRC32) Antibody, anti-human, REAfinity™
- 规格：
30 tests in 60 µL
Identification and enumeration of GARP (LRRC32)+ cells by flow cytometryClone REA166 recognizes the human glycoprotein A repetitions predominant (GARP) antigen, a 80 kDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes, platelets, and activated regulatory T cells (Treg cells). GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to non-active TGF-β. Thus, GARP as a latent TGF-β–binding protein (LTBP) regulates the surface expression of TGF-β and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGF-β is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells. | Additional information: Clone REA166 displays negligible binding to Fc receptors. |
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文献和实验该产品被引用文献
Zhou, A. X. et al. (2013) GARP-TGF-β complexes negatively regulate regulatory T cell development and maintenance of peripheral CD4+ T cells in vivo. J Immunol 190 (10): 5057–5064. | Tran, D. Q. et al. (2009) GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. U.S.A. 106: 13445–13450. | Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213–219.
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GARP (LRRC32) Antibody, anti-human, PE, REAfinity™, 30 tests in 60 µL
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