- 询价
- Miltenyi Biotec
- 德国
- 130-102-396
- 2025年12月09日
- Flow cytometry
- rat
- mouse
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- 详细信息
- 技术资料
- 免疫原：
DCAR1
- 亚型：
rat IgG2b
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
SKa5-3D5
- 标记物：
PE
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
rat
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 靶点：
DCAR1
- 抗体英文名：
DCAR1 Antibody, anti-mouse
- 抗体名：
DCAR1 Antibody, anti-mouse
- 规格：
30 µg in 1 mL
Detection of mouse DCAR1+ cellsDendritic cell immunoactivating receptor 1 (DCAR1) belongs to a subfamily of cell surface C-type lectin receptors (CLR). Mouse DCAR1 shows a tissue specific expression pattern: it is expressed on CD8a+ DC subsets in spleen and thymus and on subsets of CD11b+ myeloid cells in bone marrow and spleen. Mouse DCAR1 has neither been detected in lymph nodes nor in peripheral blood. Antigen delivered via anti-DCAR1 antibody is internalized and is cycled through the early and late endosomal compartment, inducing cellular and humoral responses in vivo. Triggering DCAR1 via monoclonal antibody ligation on CD8+ DCs increases the secretion of bioactive IL-12 whereas secretion of IL-10 is markedly reduced, indicating that antigen recognized by mDCAR1 induces enhanced proinflammatory responses. Anti-DCAR1 antibodies have been tested on BALB/c and C57BL/6 mice.
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DCAR1 Antibody, anti-mouse, PE, 30 µg in 1 mL
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