- 询价
- Miltenyi Biotec
- 德国
- 130-119-085
- 2025年12月09日
- Flow cytometry
- human cell line
- mouse
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- 详细信息
- 技术资料
- 免疫原：
DLL4
- 亚型：
recombinant human IgG1
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
REA1105
- 标记物：
Vio Bright B515
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
human cell line
- 应用范围：
Flow cytometry
- 浓度：
1:50
- 靶点：
DLL4
- 抗体英文名：
DLL4 Antibody, anti-mouse, REAfinity™
- 抗体名：
DLL4 Antibody, anti-mouse, REAfinity™
- 规格：
150 µg in 1 mL
Identification and enumeration of DLL4+ cells by flow cytometryClone REA1105 recognizes the mouse DLL4, which is one of the six identified Notch ligands in vertebrates. Being a canonical Notch ligand, extracellular domain of DLL4 contains N-terminal domain, delta/serrate/LAG-2 (DSL) domain, and tandemly arranged multiple EGF–like repeats. Binding of canonical ligands such as DLL4 induces cleavage and release of Notch intracellular domain (NICD), followed by its translocation in the nucleus where it interacts with transcription factors involved in induction of expression of Notch target genes. As a ligand for Notch1, DLL4 is the first Notch ligand to be expressed during mouse development. DLL4 plays an important role in developmental angiogenesis. In mice, lack of a single DLL4 allele leads to early embryonic lethality characterized by severe defects in arterial differentiation and vascular remodeling. | Additional information: Clone REA1105 displays negligible binding to Fc receptors.
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DLL4 Antibody, anti-mouse, Vio® Bright B515, REAfinity™, 150 µg in 1 mL
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