- 询价
- Miltenyi Biotec
- 德国
- 130-101-552
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
CD85j (ILT2)
- 亚型：
mouse IgG2bκ
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
GHI/75
- 标记物：
PE-Vio 770
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
mouse
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry
- 浓度：
1:11
- 靶点：
CD85j (ILT2)
- 抗体英文名：
CD85j (ILT2) Antibody, anti-human
- 抗体名：
CD85j (ILT2) Antibody, anti-human
- 规格：
100 tests in 1 mL
Detection of human CD85j (ILT2)+ cells by flow cytometryClone GHI/75 reacts with CD85j (ILT2), an inhibitory immunoreceptor of the immunoglobulin-like transcript (ILT) family. CD85j is a type I transmembrane protein with four extracellular Ig-like domains and four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in its cytoplasmic tail. The inhibitory signal is transmitted by recruiting SH2-containing protein tyrosine phosphatase-1 that dephosphorylates and inactivates downstream tyrosine kinases. Expression of CD85j is found on B cells, monocytes, dendritic cells, and subsets of natural killer (NK) and T cells. CD85j is known to bind classical and non-classical MHC class I molecules, human cytomegalovirus UL18 protein, and some HLA-C alleles, as ligands. Crosslinking of CD85j prevents activation of B cells, T cells, NK cells, macrophages, and downregulation of effector mechanisms, such as NK and T cells cytolytic functions.
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CD85j (ILT2) Antibody, anti-human, PE-Vio® 770, 100 tests in 1 mL
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