- 询价
- Miltenyi Biotec
- 德国
- 130-092-885
- 2025年12月09日
- Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Functional assay
- mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
CD357 (GITR)
- 亚型：
mouse IgG1κ
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
DT5D3
- 标记物：
pure
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
mouse
- 应用范围：
Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Functional assay
- 靶点：
CD357 (GITR)
- 抗体英文名：
CD357 (GITR) Antibody, anti-human
- 抗体名：
CD357 (GITR) Antibody, anti-human
- 规格：
100 µg in 1 mL
Detection of GITR expression on human T cellsCD357, also known as glucocorticoid-induced tumor necrosis factor receptor–related protein (GITR) or TNFRSF18, is an inducible type I transmembrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily. | CD357 is expressed at low levels on thymocyte subsets, resting T cells, B cells, macrophages, and at high levels on CD4+CD25+ regulatory T cells (Tregs). Upon activation, expression on CD4+ and CD8+ T cells is upregulated. Triggering of CD357 has been described to modulate Treg function and costimulate effector T cells. Stimulation of T cells through CD357 can abrogate the inhibitory function of Tregs. It is hypothesized that CD357 has a role in the maintenance of immunological self tolerance, and mouse models of autoimmune disease suggest that CD357 activation may break self-tolerance and induce autoimmunity. |
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CD357 (GITR) Antibody, anti-human, pure, 100 µg in 1 mL
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