- 询价
- Miltenyi Biotec
- 德国
- 130-113-193
- 2025年12月09日
- Flow cytometry, Mass cytometry
- mouse
- human, non-human primate
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- 详细信息
- 技术资料
- 免疫原：
CD303 (BDCA-2)
- 亚型：
mouse IgG1κ
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
AC144
- 标记物：
PE
- 适应物种：
human, non-human primate
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
mouse
- 应用范围：
Flow cytometry, Mass cytometry
- 浓度：
1:50
- 靶点：
CD303 (BDCA-2)
- 抗体英文名：
CD303 (BDCA-2) Antibody, anti-human
- 抗体名：
CD303 (BDCA-2) Antibody, anti-human
- 规格：
100 tests in 200 µL
Detection of human plasmacytoid dendritic cells in blood, lymphoid, and non-lymphoid tissuesCD303 (BDCA-2) antibodies have been used, for example, to identify, characterize, and enumerate plasmacytoid dendritic cells in whole blood of healthy and HIV-infected individuals, and for analyzing the role of DC-SIGN in HIV infection and transmission.7,11 Furthermore, CD303 (BDCA-2) antibodies were used to identify and enumerate plasmacytoid dendritic cells in blood and bone marrow samples before and after hematopoietic stem cell mobilization 8) or transplantation 10). CD303 (BDCA-2) antibodies were also used for immunohistochemical staining, for example to identify plasmacytoid dendritic cells in tissue sections from patients with different inflammatory skin diseases.5,12,13 | Clone AC144 recognizes the the CD303 (BDCA-2) antigen1,3 which is expressed on human plasmacytoid dendritic cells in blood, lymphoid (e.g. tonsils and bone marrow) and non-lymphoid tissue.3,6 Specific expression allows direct identification of plasmacytoid dendritic cells using just one marker.1–11 CD303 (BDCA-2)+ plasmacytoid dendritic cells in blood and bone marrow are CD11c–, CD123high, CD4+, Lin–, CD45RA+, CD304 (BDCA-4/Neuropilin-1)+, CD141 (BDCA-3)low, CD1c (BDCA-1)–, CD14–, and CD2–. They express neither myeloid lineage markers (CD13, CD33) nor Fc receptors (CD32, CD64, FcRI).1,6 CD303 (BDCA-2) is strongly expressed on freshly isolated plasmacytoid dendritic cells but down-regulated within 48 hours of culturing. 1) Unlike CD304 (BDCA-4/Neuropilin-1), CD303 (BDCA-2) is not detectable on ex vivo generated monocyte-derived or hematopoietic precursor cell-derived CD1a+ dendritic cells.1,9 | The CD303 (BDCA-2) antigen is a novel type II transmembrane C-type lectin. 3) Remarkably, plasmacytoid dendritic cells can take up ligands via CD303 (BDCA-2), then process and present the ligands to T cells.1,3 Unlike binding of antibodies to CD304 (BDCA-4), binding of antibodies to CD303 (BDCA-2) inhibits type I IFN production, which is induced in plasmacytoid dendritic cells by, for example, the influenza virus.3,6
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CD303 (BDCA-2) Antibody, anti-human, PE, 100 tests in 200 µL
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