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- 详细信息
- 技术资料
- 免疫原:
CD278 (ICOS)
- 亚型:
rat IgG2bκ
- 形态:
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件:
避光,2-8℃
- 克隆性:
7E.17G9
- 标记物:
APC-Vio 770
- 适应物种:
mouse
- 保质期:
24个月
- 供应商:
Miltenyi Biotec
- 宿主:
rat
- 应用范围:
Flow cytometry
- 浓度:
1:10
- 靶点:
CD278 (ICOS)
- 抗体英文名:
CD278 (ICOS) Antibody, anti-mouse
- 抗体名:
CD278 (ICOS) Antibody, anti-mouse
- 规格:
30 µg in 1 mL
Identification and enumeration of CD278 (ICOS)+ cells by flow cytometryClone 7E.17G9 reacts with CD278, the inducible co-stimulatory molecule (ICOS), a 47–57 kDa homodimeric glycoprotein of the CD28 family. Directly ex vivo, CD278 is expressed only by a small subset of T cells, including follicular B helper T cells (TFH) and regulatory T cells. However, CD278 is strongly up-regulated on the surface following T cell activation. Upon binding to its ligand (ICOSL), CD278 initiates a multitude of events, which modulate many different aspects of T cell–mediated immune responses. Besides regulating differentiation and activation of effector as well as regulatory CD4+ T cells, ICOS also plays a role in germinal center formation and isotype switching.
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CD278 (ICOS) Antibody, anti-mouse, APC-Vio® 770, 30 µg in 1 mL
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