TIM-1 Antibody, anti-mouse, PE

Identification and enumeration of TIM-1+ cells by flow cytometryClone RMT1-17 recognizes the mouse T-cell immunoglobulin mucin receptor 1 (TIM-1) antigen, a Single-pass type I membrane protein also known as Hepatitis A virus cellular receptor 1 (HAVcr-1) or kidney injury molecule 1 (KIM-1). The TIM gene family is involved in a variety of immunity related processes including T cell proliferation and survival, tissue inflammation, and atopy. In mice, eight TIM genes encode the proteins TIM-1 to TIM-8, whereas only three TIM genes are found in humans encoding TIM-1, TIM-3, and TIM-4. Several lines of evidence suggest that TIM-1 regulates T cell activity in vivo through responses mediated by Th1, Th2, Th17, and regulatory T cells. TIM-1 is recruited to the T cell receptor signaling complex and has a costimulatory role. TIM-1 expression has been demonstrated in epithelial cells, especially those of kidney origin, and is greatly increased in both mouse and human kidneys after injury. While absent on naïve CD4 T cells, TIM-1 expression increases following TCR stimulation to provide positive co-stimulatory signal in T cell proliferation and Th1/Th17 cytokine production.