- 询价
- Miltenyi Biotec
- 德国
- 130-096-382
- 2025年12月09日
- Flow cytometry
- mouse
- human
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- 详细信息
- 技术资料
- 免疫原：
TIGIT
- 亚型：
mouse IgG3κ
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
4E1.2
- 标记物：
Biotin
- 适应物种：
human
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
mouse
- 应用范围：
Flow cytometry
- 浓度：
1:11
- 靶点：
TIGIT
- 抗体英文名：
TIGIT Antibody, anti-human
- 抗体名：
TIGIT Antibody, anti-human
- 规格：
100 tests in 1 mL
Detection of human TIGIT+ cells, such as subsets of T cells and NK cellsClone 4E1.2 reacts with a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM), which is called TIGIT (T cell immunoglobulin and ITIM domain). It is expressed on T cells, including Treg cells and memory subsets, as well as on NK cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of IL-10 production in DCs, exerting an inhibitory effect on T cell activation.
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TIGIT Antibody, anti-human, Biotin, 100 tests in 1 mL
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