- 询价
- Miltenyi Biotec
- 德国
- 130-102-008
- 2025年12月09日
- Flow cytometry
- mouse
- mouse
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- 详细信息
- 技术资料
- 免疫原：
Ly-49A
- 亚型：
mouse IgG2aκ
- 形态：
Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
- 保存条件：
避光，2-8℃
- 克隆性：
A1
- 标记物：
Biotin
- 适应物种：
mouse
- 保质期：
24个月
- 供应商：
Miltenyi Biotec
- 宿主：
mouse
- 应用范围：
Flow cytometry
- 浓度：
1:10
- 靶点：
Ly-49A
- 抗体英文名：
Ly-49A Antibody, anti-mouse
- 抗体名：
Ly-49A Antibody, anti-mouse
- 规格：
9 µg in 300 µL
Identification and enumeration of Ly-49A+ cells by flow cytometry.Clone A1 recognizes Ly-49A, an inhibitory cell surface receptor belonging to the Ly-49 receptor family. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK-T cells. Ly-49 family members are both activating and inhibitory receptors and are mainly receptors for MHC class I molecules. Ly-49A interacts strongly with MHC class Ia molecules such as H-2Dd, H-2Dk and weakly with H-2Db. An inhibitory signal is delivered by Ly-49A engagement via the phosphorylation of immunoreceptor tyrosine based inhibition motif (ITIM) and recruitment of phosphatases SHP-1 and SHP-2. Recognition of cognate ligand bearing cells leads to inhibition of cytotoxic killing of cells by NK cells.
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Ly-49A Antibody, anti-mouse, Biotin, 9 µg in 300 µL
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