IL-17A Antibody, anti-human, A

Intracellular staining of IL-17A–producing human or non-human primate cellsClone CZ8-23G1 detects human interleukin 17 (IL-17). Interleukin 17A (CTLA8), a member of the IL-17 family (IL-17A–F), is a disulfide-linked homodimeric glycoprotein. Human IL-17A consists of 155 amino acids with a molecular weight of around 35 kDa. IL-17A is produced by CD4+ T helper (Tʜ) cells, a third T cell subset termed Tʜ17, which secrete also cytokines such as IL-17F and IL-22 and express the NK cell marker CD161. IL-17A secretion has also been described for other cell types, such as CD8+ memory T cells. Furthermore, intracellular IL-17A has also been detected in eosinophils, neutrophils, and blood monocytes. Emerging data about Tʜ17 cells suggest that these cells are involved in the recruitment of neutrophils to control early stages of infections to a number of pathogens, such as extracellular bacteria and fungi. IL-17A and Tʜ17 cells have been shown to play an important role in immune-mediated diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, asthma, inflammatory bowel diseases, and other immune-mediated inflammatory conditions. | Depending on the cytokine milieu present at time of the initial engagement, CD4+ naive T cells can differentiate into various subsets (Tʜ1, Tʜ2, and Tʜ17). For the differentiation into Tʜ17 cells several cytokines have been described, including TGF-β, IL-1β, IL-6, IL-21, and IL-23. RORγt was identified as the master regulator gene for Tʜ17 cells. |