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- 2025年12月09日
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货期：询盘
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MedChemExpress LLC
- CAS号：
945152-88-5
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1 mg
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Antiviral agent 34
CAS No. : 945152-88-5
MCE 国际站：Antiviral agent 34
产品活性：Antiviral agent 34 是一种强效且口服有效的抗甲型和乙型流感亚型抗病毒药物，对 H1N1 增殖的 EC50 值为 0.8 nM。Antiviral agent 34 通过靶向流感病毒 RNA 依赖性 RNA 聚合酶来抑制流感病毒的增殖。Antiviral agent 34 可用于流感病毒的研究。
研究领域：Anti-infection
作用靶点：Influenza Virus
In Vitro: Antiviral agent 34 (Compound 10m) (0-470 nM, 24 h) demonstrates a high safety profile and inhibits the H1N1 virus proliferation.
In Vivo: Antiviral agent 34 (Compound 10m) (1 g/kg for orally administration, three times a day and continues for 14 days) exhibits antiviral activity in a lethal influenza virus mouse model.
Pharmacokinetic Analysis in SD rats
| Route | Dose (mg/kg) | AUClast (ng•h/mL) | AUCINF_obs (ng•h/mL) | t1/2 (h) | Tmax (h) | Cmax (ng/mL) | Clobs (L•h/kg) | Vss_obs (mL/kg) | MRTINF_obs (h) | F (%) |
| i.v. | 3 | 21944 | 21920 | 3.69 | 0.08 | 41942 | 2.29 | / | / | / |
| p.o. | 10 | 5416 | 5395 | 3.26 | 4.0d | 1184 | / | / | / | 7.38 |
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文献和实验Catalytic M1GS RNA as an Antiviral Agent in Animals
The use of RNase P ribozyme (M1GS catalytic RNA) for inhibition of murine cytomegalovirus (MCMV) propagation in mice is described in this chapter. General information about RNase P based technology is included and followed by detailed
RNase P Ribozyme As an Antiviral Agent Against Human Cytomegalovirus
immunodeficiency syndrom (AIDS) patients (e.g., CMV-associated retinitis and pneumonia), and possibly cardiovascular diseases such as atherosclerosis. This chapter describes the utilization of RNase P ribozyme—specifically, M1GS ribozyme, as a gene-targeting agent
Antiviral Screening Assays for Human Herpesviruses 6 and 7
associated with a specific disease but may contribute to disease in immunocompromised patients; variant B is the major etiologic agent of roseola (roseola infantum or exanthem subitum) and other febrile illnesses of young children, and has been associated
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