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- 详细信息
- 文献和实验
- 技术资料
- 抗体名:
Cyclin E2 Rabbit mAb抗体
- 抗体英文名:
Cyclin E2 Rabbit mAb
- 靶点:
CCNE2
- 浓度:
0.3 mg/ml
- 应用范围:
ICC, IF, IHC-Fr, IHC-P, WB
- 适应物种:
Human
- 保质期:
6-12个月
- 抗原来源:
详询
- 目录编号:
orb1565030
- 级别:
科研级
- 库存:
88
- 供应商:
biorbyt
- 标记物:
Unconjugated
- 克隆性:
Monoclonal
- 保存条件:
参考说明书
- 形态:
Liquid
- 亚型:
IgG
- 免疫原:
A synthetic peptide of human Cyclin E2
- 规格:
20 ul
别名:CCNE2; G1/S-specific cyclin-E2
免疫原:A synthetic peptide of human Cyclin E2
克隆性:R02-1C0
分子量:Calculated MW: 47 kDa; Observed MW: 47 kDa
应用稀释比例:WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
防腐剂:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% rAlbumin.
纯化:Affinity Purified
保存说明:Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
UniProt ID:O96020
Note:For research use only.



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文献和实验Assays for Cyclin-Dependent Kinase Inhibitors
of the Retinoblastoma gene product (Rb) by CDK4 and/or CDK6 (G1/S checkpoint), leading to the release of bound E2F from Rb and allowing the transcription of genes by “free E2F” necessary for S phase progression. During late G1 phase, CDK2/cyclin E complex phosphorylates
E2F Transcription Factors and pRb Pocket Proteins in Cell Cycle Progression
The E2F-family of transcripion factors exerts fascinating and contrasting functions in tran-scriptional repression and activation of genes regulating proliferation, apoptosis, and differentiation. E2F is principally regulated by its temporal
3 篇 Nature 连发,解决世纪难题,周期蛋白的毁灭调控蕴含癌症患者的新生
在 cyclin D 上,被泛素化标记的 cyclin D 将会被蛋白酶体降解。此外研究还发现,AMBRA1 缺失会导致 cyclin D 和 MYC 蛋白水平升高。cyclin D 与 CDK4/6 结合,使 RB1 蛋白磷酸化。磷酸化 RB1 释放 E2F 转录因子来驱动细胞周期进程所需基因的表达。在 AMBRA1 缺失的细胞中,cyclin D 也能与 CDK2 激酶形成复合物,使癌细胞能够抵抗 CDK4/6 抑制剂的治疗。高水平的 cyclin D 会促进细胞增殖,从而导致 DNA 损伤、复制应激
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