- ￥12090
- biorbyt
- orb1269986
- 英国
- 2025年12月07日
- IF, IHC-P, WB
- Human
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
TRPM8 Antibody抗体
- 抗体英文名：
TRPM8 Antibody
- 靶点：
TRPM8
- 浓度：
batch dependent
- 应用范围：
IF, IHC-P, WB
- 适应物种：
Human
- 保质期：
6-12个月
- 抗原来源：
详询
- 目录编号：
orb1269986
- 级别：
科研级
- 库存：
88
- 供应商：
biorbyt
- 标记物：
Unconjugated
- 克隆性：
Polyclonal
- 形态：
Liquid
- 亚型：
Rabbit Ig
- 免疫原：
This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human TRPM8.
- 规格：
400 ul
别名:Transient receptor potential cation channel subfamily M member 8, Long transient receptor potential channel 6, LTrpC-6, LTrpC6, Transient receptor potential p8, Trp-p8, TRPM8, LTRPC6, TRPP8
免疫原：This TRPM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-292 amino acids from the Central region of human TRPM8.
分子量:128 kDa
应用注释：For WB starting dilution is: 1:1000For IHC-P starting dilution is: 1:50~100For IF starting dilution is: 1:10~50
防腐剂:Supplied in PBS with 0.09% (W/V) sodium azide.
纯化:This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
保存说明:Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
NCBI:Q7Z2W7
UniProt ID:Q7Z2W7
Note:For research use only.
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文献和实验TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation
, the latter influential in the discovery of TRPM8, the first TRP channel shown to be responsive to cold temperatures. TRPM8, a member of the melastatin TRP channel subfamily, is a receptor for a number of cold mimetics such as menthol and icilin, and is activated
官方解读：我们如何感知温度和疼痛？这篇文章帮你看懂今年诺奖成果
了！进一步的实验表明，该基因编码了一种新的离子通道蛋白，这一新发现的辣椒素受体后来被命名为 TRPV1。当 Julius 研究这种蛋白质对热的反应能力时，他意识到他发现了一种热感受器，这种感受器在感觉疼痛的温度下被激活。TRPV1 的发现是一个重大突破，引领并解开其他温度敏感受体研究的道路。David Julius 和 Ardem Patapoutian 各自独立地使用化学物质薄荷醇来识别 TRPM8，一种被证明能被寒冷激活的受体。另外还发现了与 TRPV1 和 TRPM8 相关的离子通道，并发
Transient Receptor Potential Channels and Pruritus
and hair morphogenesis. TRPM8 and TRPA1 interfere with the induction of sensory sensations. Cutaneously expressed temperature sensors of the TRP channel family thus became an attractive target for pharmacological treatment of pruritic, inflammatory
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