Acetyl coenzyme A trilithium乙酰

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Acetyl coenzyme A trilithium

CAS No. : 75520-41-1

MCE 国际站：Acetyl coenzyme A trilithium

产品活性：Acetyl coenzyme A trilithium 是一种膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A trilithium 通过向目标氨基酸残基提供 (唯一供体) 乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A trilithium 也是脂质合成的关键前体。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：Endogenous Metabolite  |  Autophagy

In Vitro: Acetyl coenzyme A trilithium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h).

In Vivo: Acetyl coenzyme A trilithium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy. Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A concentrations in the brain and actually increase hepatic Acetyl coenzyme A and protein acetylation levels.

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