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Cecropin P1, porcine acetate
MCE 国际站：Cecropin P1, porcine acetate
产品活性：Cecropin P1, porcine acetate 是一种抗菌 (antibacterial) 肽，可从猪小肠上部分离。Cecropin P1, porcine acetate 对革兰氏阴性菌具有抗菌活性。Cecropin P1, porcine acetate 具有抗病毒 (antiviral) 活性，可抑制 PRRSV 感染。
研究领域：Anti-infection | Metabolic Enzyme/Protease
作用靶点：Bacterial | Endogenous Metabolite
In Vitro: Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells.
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation.
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection.
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release.
In Vivo: Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock.
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文献和实验-Jun Park, Soo Young Choi, and Hee-Bong Lee(2006)A carboxylesterase from the thermoacidophilic archaeon Sulfolobus solfataricus P1; purification, characterization, and expression.Biochimica et Biophysica (BBA) - General Subjects 1760(5):820-828.Andrey
mol/L resulted in a higher expression level of Bcl-2 and lower expression level of Bax, which were 8.81% and 3.83% respectiv ely, as compared with that of the control group (15.33%) (P1＜0.01, P2＜0.01).CONCLUSION: Arsenic trioxide not only inhibited
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