Captopril,198342-23-3

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Captopril hydrochloride

CAS No. : 198342-23-3

MCE 国际站：Captopril hydrochloride

产品活性：Captopril (SQ 14225) hydrochloride 是一种含巯基的口服活性血管紧张素转换酶 (ACE) 抑制剂 (IC₅₀=0.025 μM)，广泛应用于高血压和充血性心力衰竭的研究。Captopril hydrochloride 也是 NDM-1 抑制剂，IC₅₀ 值为 7.9 μM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Angiotensin-converting Enzyme (ACE)

In Vitro: Captopril (SQ 14225) hydrochloride has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril hydrochloride has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes.
An equimolar ratio of the cis and trans states of Captopril hydrochloride exists in solution and that the enzyme selects only the trans state of the inhibitor that presents architectural and stereoelectronic complementarity with its substrate binding groove.

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