2-Hydroxyestrone2-羟雌甾酮,362-06-

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2-Hydroxyestrone

CAS No. : 362-06-1

MCE 国际站：2-Hydroxyestrone

产品活性：2-Hydroxyestrone (Catecholestrone) 是一种特异性受体介导的抗雌激素剂。2-Hydroxyestrone 具有抗癌作用。

研究领域：Metabolic Enzyme/Protease  |  Vitamin D Related/Nuclear Receptor

作用靶点：Endogenous Metabolite  |  Estrogen Receptor/ERR

In Vitro: 2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells.

In Vivo: Levels of both 2-Hydroxyestrone (2-OHE1; 2 mg/kg; administered ip.) and  2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups.

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