Malvidin-3-galactoside氯化锦葵色素-3

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Malvidin-3-galactoside chloride

CAS No. : 30113-37-2

MCE 国际站：Malvidin-3-galactoside chloride

产品活性：Malvidin-3-galactoside chloride 是一种花青素单体，可诱导肝细胞癌 (HCC) 细胞周期停滞和凋亡。Malvidin-3-galactoside chloride 抑制 ROS 的产生和积累。Malvidin-3-galactoside chloride 具有抗肿瘤功能。

研究领域：Apoptosis  |  Protein Tyrosine Kinase/RTK

作用靶点：Apoptosis  |  ROS

结构分类：酚类  |  多酚类  |  黄酮类  |  花色素类

来源：植物  |  其他科

In Vitro: Malvidin-3-galactoside chloride (50, 100, 200 μg/mL; for 24, 48, 72 h) displays obvious cytotoxicity on Huh-7 cells and has no significant effect with 50 and 100 μg/mL for 48 h. Malvidin-3-galactoside chloride has a notable cytotoxic effect against Huh-7 cells at 72 h.
Malvidin-3-galactoside chloride (50-200 μg/mL) arrests the cells in the S phase, accompanied by the cells in the G1 phase decreased, and the cells in the S phase increased.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) induces cell apoptosis in Huh-7 cells.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 72 h) markedly increased the levels of caspase-3, cleaved-caspase-3 and cleaved-PARP in a dose-dependent manner.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the production and accumulation of ROS.
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) dramatically reduces the level of phosphorylation ERK (p-ERK) in a dose-dependent manner. Malvidin-3-galactoside chloride with 200 μg/mL markedly increases the phosphorylation level of p38 and JNK (p-p38 and p-JNK).
Malvidin-3-galactoside chloride (50-200 μg/mL; for 12 h) inhibits the migration and invasion in Huh-7 cells.

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