RFRP-3(human)

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RFRP-3(human) TFA

CAS No. :

MCE 国际站：RFRP-3(human) TFA

产品活性：RFRP-3 TFA efficiently inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.
Scatchard-plot analysis shows that ¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_d value and the B_max values are 0.19 nM and 1.3 pM, respectively.
RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM).
RFRP-3 (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.

研究领域：GPCR/G Protein  |  Neuronal Signaling

作用靶点：Neuropeptide Y Receptor

In Vitro: RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC₅₀ of 0.7 nM.
Scatchard-plot analysis shows that ¹²⁵I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K_d value and the B_max values are 0.19 nM and 1.3 pM, respectively.
RFRP-3 TFA specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K_d= 0.19 nM).
RFRP-3 TFA (10^-8 to 10^-14M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.

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