Omilancor,1912399-75-7

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

BT-11

CAS No. : 1912399-75-7

MCE 国际站：BT-11

产品活性：BT-11 是用于研究炎症性肠病，有口服活性的结合 LANCL2 的化合物。

研究领域：Others

作用靶点：Others

In Vitro: LANCL2 engagement produces an increase of PKA, followed by an accumulation of cAMP in the cytoplasm. BT-11 treatment splenocytes shows a dose−response increase of cAMP production. BT-11 stimulates cAMP production by activating the LANCL2 pathway.

In Vivo: The oral treatment with BT-11 (8 mg/kg/d) in a mouse model of inflammatory bowel disease results in lowering the disease activity index, decreasing colonic inflammatory lesions by 4-fold, and suppressing inflammatory markers (e.g., TNF-α, and interferon-γ) in the gut. Furthermore, studies in LANCL2^−/− mice demonstrates that loss of LANCL2 abrogates beneficial actions of BT-11, suggesting high selectivity for the target. Oral treatment with BT-11 (8 mg/kg/day) ameliorates colitis in mice. Initial safety assessment in rats indicates that oral treatment with BT-11 at high doses has an excellent safety profile up to 1000 mg/kg/day. BT-11 is well tolerated in rats, and may hold promise as an orally active therapeutic for Crohn’s disease. One hour after oral administration of a single dose of 80 mg/kg, BT-11 has a maximal concentration of 21 ng/mL; the half-life is 3 hours.

相关产品：PEG300  |  SBE-β-CD  |  Corn oil  |  Tween 80  |  D-Lin-MC3-DMA  |  Solutol HS-15  |  Auxinole  |  JC-1  |  CFSE  |  Digitonin  |  DTT  |  Thiazolyl Blue  |  Monocrotaline  |  (2-Hydroxypropyl)-β-cyclodextrin  |  Methyl-β-cyclodextrin  |  D-Luciferin potassium salt  |  Biotin  |  O-Propargyl-Puromycin  |  Propidium Iodide  |  DAPI dihydrochloride  |  Tocofersolan  |  Nile Red  |  Calcein-AM  |  3X FLAG peptide TFA  |  IPTG  |  Lipopolysaccharides  |  ISA-2011B  |  FLAG peptide

品牌介绍:
•   MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最全的高品质小分子活性化合物；
•   10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪制药及生命科学研究进展，为您提供全球活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。