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- MedChemExpress(MCE)
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- HY-P1339A
- 2025年12月06日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
polypeptide, sealed storage, away from moisture
- 英文名：
Human orexin B TFA
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
1 mg/5 mg/10 mg
| 规格： | 1 mg | 产品价格： | ￥805.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥2030.0 |
| 规格： | 10 mg | 产品价格： | ￥3255.0 |
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Orexin B, human TFA
MCE 国际站：Orexin B, human TFA
产品活性：Orexin B, human (TFA) 是 Orexin 受体的内源性激动剂，与OX1和OX2结合的 Ki 值分别为 420 和 36 nM。
研究领域：GPCR/G Protein | Neuronal Signaling
作用靶点：Orexin Receptor (OX Receptor)
In Vitro: Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor.
Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.
In Vivo: Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.
相关产品：Bioactive Compound Library Plus | Peptide Library | Lemborexant | Almorexant | Orexin A (human, rat, mouse) (TFA) | SB-334867 free base | Orexin 2 Receptor Agonist | TCS 1102 | Filorexant | Seltorexant | MK-1064 | Nemorexant | SB-649868 | TCS-OX2-29 | GSK1059865 | JNJ-10397049 | SB-674042 | EMPA | IPSU | SB-408124 | MK-3697 | Orexin 2 Receptor Agonist 2 | Orexin B, rat, mouse | Orexin B, rat, mouse TFA | Orexin receptor antagonist 2 | Orexin receptor antagonist 3 | Almorexant-13C,d3 | Danavorexton | Firazorexton
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