LAH4,184776-51-0

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LAH4

CAS No. : 184776-51-0

MCE 国际站：LAH4

产品活性：LAH4 是两亲性肽抗生素的 α 螺旋，具有强大的抗菌 (antimicrobial)、核酸转染(nucleic acid transfection) 和细胞渗透活性。LAH4 具有较高的质粒 DNA 传递能力。LAH4 对细菌膜外膜中的阴离子脂质有很强的亲和力。

研究领域：Anti-infection

作用靶点：Bacterial

In Vitro: LAH4 is capable of complexing DNA, associating with the cell surfacemembrane and then, when enveloped within an endosome, disrupts the endosomal membrane as the pH drops.
LAH4 possesses robust plasmid DNA transfection properties. Peptides of the LAH4 family are able to efficiently deliver siRNAs in vitro into a human cell line.
LAH4 is found to mediate the intracellular delivery of both protein and nucleotide cargo and facilitate protein internalization using mechanisms involving endosomal acidification and processing through the proteasome pathway, leading to enhanced cross presentation of protein antigen by dendritic cells to CD8+ T cells. LAH4 also improves the internalization of CpG, resulting in NF-kB activation, thus potentiating the adjuvant effect of CpG.
LAH4 exhibits antibiotic activities against Escherichia coli and Bacillus subtilis. the peptide does not, however, lyse human red blood cells at bacteriocidal concentrations. The antibiotic activities of LAH4 are 2 orders of magnitude more pronounced at pH 5 when compared with pH 7.5.

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