Vinorelbine ditartrate酒石酸长春瑞滨,

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Vinorelbine ditartrate

CAS No. : 125317-39-7

MCE 国际站：Vinorelbine ditartrate

产品活性：Vinorelbine ditartrate 是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC₅₀值为 1.25 nM。

研究领域：Cell Cycle/DNA Damage | Cytoskeleton | Autophagy

作用靶点：Microtubule/Tubulin | Autophagy

结构分类：生物碱 | 生物碱二聚体

来源：植物 | 夹竹桃科 | 长春花

In Vitro: Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC₅₀) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase. Vinorelbine time-dependently induces the p53 and p21^WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner.

In Vivo: After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth(1) vinorelbine treatment in the dogs. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m².

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