- ￥1560
- biorbyt
- orb515545
- 英国
- 2025年12月05日
- WB
- Rabbit
- Bovine, Human, Monkey, Mouse, Porcine, Rat
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- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
EGFR Antibody抗体
- 抗体英文名：
EGFR Antibody
- 应用范围：
WB
- 宿主：
Rabbit
- 适应物种：
Bovine, Human, Monkey, Mouse, Porcine, Rat
- 保质期：
6-12个月
- 抗原来源：
详询
- 目录编号：
orb515545
- 级别：
科研级
- 库存：
88
- 供应商：
biorbyt
- 标记物：
Unconjugated
- 克隆性：
Polyclonal
- 形态：
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
- 免疫原：
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EGFR. The exact sequence is proprietary.
- 规格：
30 ul
别名:ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
免疫原：KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human EGFR. The exact sequence is proprietary.
应用稀释比例：WB: 1:500-1000
纯化:The antibody was purified by immunogen affinity chromatography.
保存说明:Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Entrez:13649, 1956
UniProt ID:P00533, Q01279
Note:For research use only.
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文献和实验受体阳性的乳腺癌细胞有较小程度的细胞毒性，这种情况与在异种移植小鼠模型中的表现一致。体外实验中，在 TNBC 细胞的诱导下，初始 EGFR CAR-T 迅速扩增，同时还会激活 interferomγ, granzyme-perforin-PARP 和 FaS-FADD-caspase 等相关信号通路。 实验团队首先通过免疫印迹和流式细胞术的方法验证 EGFR 高表达于三阴乳腺癌。其中免疫印迹（immunoblotting）又称蛋白质印迹（Western blotting），是根据抗原抗体的特异性结合检测
Clinical Advancement of EGFR Inhibitors in Cancer Therapy
The epidermal growth factor receptor (EGFR) represents one of the most promising molecular targets in cancer therapeutics. An array of EGFR inhibitory drugs have been developed that are progressing rapidly in oncology clinical trials
Phosphotyrosine Kinase Assays as a Prescreen for Inhibitors of EGFr
The epidermal growth factor receptor (EGFr) is a 170-kDa glycosylated transmembrane protein found in a wide variety of tissues (1 ). It is the receptor for epidermal growth factor (EGF), transforming growth factor α (TGFα), and other related
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