GABA B Receptor 1 Antibody (HR

产品描述：Mouse monoclonal to GABA-B R 1 (HRP). GABA (gamma-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modulate slow inhibitory synaptic transmission. Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site. Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein. G proteins subsequently inhibit adenyl cylase activity and modulate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release through suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit through coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation..

别名:GABA-B receptor 1, GABA-B-R1, GABR1_HUMAN, Gamma aminobutyric acid receptor 1, GB1, GPRC3A, Gamma-aminobutyric acid type B receptor subunit 1, GABBR1

免疫原：Fusion protein amino acids 873-977 (cytoplasmic C-terminus) of rat GABA(B)R1

克隆性:N93A/49 (Formerly sold as S93A-49)

分子量:115kDa

应用稀释比例：WB (1:1000)

应用注释：1 µg/ml of SMC-403 was sufficient for detection of GABA(B)R1 in 20 µg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

防腐剂:73.64mM Carbonate, 54.55mM Ethanolamine, 45.45mM Cyanoborohydride, 18.18mM Sodium Hydroxide 0.23mM Citrate

纯化:Protein G Purified

保存说明:Conjugated antibodies should be stored according to the product label

NCBI:NP_112290.2

Entrez:81657

UniProt ID:Q9Z0U4

Note:For research use only.