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- Bioss
- bs-6827R-BF350
- 2025年12月01日
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100ul
| 产品编号 | bs-6827R-BF350 |
| 英文名称 | MAGEC2 Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的黑色素瘤相关抗原C2抗体 |
| 英文别名 | Cancer testis antigen 10; Cancer/testis antigen 10; CT10; HCA587; Hepatocellular carcinoma associated antigen 587; Hepatocellular carcinoma-associated antigen 587; MAGC2_HUMAN; MAGE C2 antigen; MAGE E1 antigen; MAGE-C2 antigen; MAGE-E1 antigen; MAGEC2; Melanoma associated antigen C2; Melanoma-associated antigen C2; MGC13377. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MAGEE1/MAGEC2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Tumor biomarkers > Tumor antigens Cancer > Tumor immunology > Tumor-associated antigens |
| 亚基 | Interacts with TRIM28 and UBE2H. |
| 亚细胞定位 | Cytoplasm. Nucleus. Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma. |
| 组织特异性 | Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. |
| 相似性 | Contains 1 MAGE domain. |
| 功能 | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Tissue specificity; Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non-small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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MAGEC2 Rabbit pAb, BF350 conjugated(bs-6827R-BF350)-100ul
￥2980
