TOP1 | Topoisomerase I Rabbit pAb, APC-Cy7 conj.(bs-23144R-APC-Cy7)-100ul产品图

TOP1 | Topoisomerase I Rabbit

pAb, APC-Cy7 conj.(bs-23144R-APC-Cy7)-100ul
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  • ¥2980
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  • bs-23144R-APC-Cy7
  • 2026年10月17日
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    • 规格:

      100ul

    产品编号bs-23144R-APC-Cy7
    英文名称Topoisomerase I Rabbit pAb, APC-Cy7 conjugated
    中文名称APC-Cy7标记的拓普西异构酶Ⅰ抗体
    英文别名DNA topoisomerase 1; DNA topoisomerase I; NUP98 fusion gene; TOP 1; TOP I; TOP1; TOP1_HUMAN; TOPI; Topoisomerase 1; Topoisomerase1; TopoisomeraseI; Type I DNA topoisomerase.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Topoisomerase I
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis > Topoisomerases

    亚细胞定位Nucleus, nucleolus. Nucleus, nucleoplasm. Diffuse nuclear localization with some enrichment in nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli.
    翻译后修饰Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment.
    相似性Belongs to the eukaryotic type I topoisomerase family.
    功能The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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