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- Bioss
- bs-41345R-BF350
- 2025年12月01日
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100ul
| 产品编号 | bs-41345R-BF350 |
| 英文名称 | SPARC Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的富含半胱氨酸的酸性分泌蛋白抗体 |
| 英文别名 | AA517111; Basement membrane protein 40; BM 40; BM40; Cysteine rich protein; hm:zeh0062; MGC128090; ON; Osteonectin; Secreted acidic cystein rich glycoprotein; Secreted protein acidic and rich in cysteine; Secreted protein acidic cysteine rich(osteonectin); Secreted protein acidic cysteine rich; SPRC; SPRC_HUMAN. |
| 产品应用 | IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | Recombinant human SPARC protein |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Tyrosine kinases > Receptor tyrosine kinases Cardiovascular > Angiogenesis > Adhesion / ECM > Extracellular Matrix Cell Biology > Cell Cycle > Cell Cycle Inhibitors Developmental Biology > Lineage specification > Endoderm Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Receptor Tyrosine Kinases Stem Cells > Lineage Markers > Endoderm Stem Cells > Mesenchymal Stem Cells > Osteogenesis |
| 亚细胞定位 | Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane. |
| 相似性 | Belongs to the SPARC family. Contains 1 EF-hand domain. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain. |
| 功能 | Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. [provided by RefSeq, Dec 2011]. |
| 应用 | 推荐稀释比例 |
| {IF} | {1:100-500} |
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