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OVOL2 Rabbit pAb, BF350 conjug

ated(bs-12274R-BF350)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-12274R-BF350
  • 2025年12月01日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-12274R-BF350
    英文名称OVOL2 Rabbit pAb, BF350 conjugated
    中文名称BF350标记的锌指蛋白339抗体
    英文别名bA504H3.3; EUROIMAGE566589; hOvo 2; hOvo2; Ovo like 2(Drosophila); Ovo like 2; OVOL 2; Transcription factor Ovo like 2; Zinc finger protein 339; ZNF 339; ZNF339; OVOL2_HUMAN.
    产品应用IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human OVOL2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Developmental Biology > Reproduction > Germ cell markers

    Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding

    Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger

    Stem Cells > Germline Stem Cells > Embryonic Germ Cells

    亚细胞定位Nuclear.
    组织特异性Expressed in testis, ovary, heart and skeletal muscle.
    相似性Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 4 C2H2-type zinc fingers.
    功能OVOL2 (Ovo like 2) contains 4 C2H2 type zinc fingers. It belongs to the krueppel C2H2 type zinc finger protein family. It is a DNA binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. It probably acts as a transcription regulator.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental signaling pathways such as Wnt and TGF-∫/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis.

     

    应用推荐稀释比例
    {IF}{1:100-500}

     

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