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- bs-11000R-PE
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100ul
| 产品编号 | bs-11000R-PE |
| 英文名称 | Jarid1C Rabbit pAb, PE conjugated |
| 中文名称 | PE标记的组蛋白去甲基化Jarid1C抗体 |
| 英文别名 | SmcX protein; Xe169 protein; DXS1272E; Histone demethylase JARID1C; JmjC domain containing protein SMCX; Jumonji AT rich interactive domain 1C; Jumonji/ARID domain-containing protein 1C; KDM5C; KDM5C_HUMAN; Lysine(K) specific demethylase 5C; Lysine-specific demethylase 5C; MRXJ; MRXSCJ; MRXSJ; Protein SmcX; Protein Xe169; rbp2 like protein; Selected cDNA on X; Smcx homolog X chromosome; SmcX protein; Smcy homolog X linked; XE169; Xe169 protein. |
| 产品应用 | ICC/IF=1:50-200, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Jarid1C |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > ChIP assays > ChIP antibodies Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Jumonji containing proteins Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Co-activators/co-repressors Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Other factors |
| 亚基 | Part of two distinct complexes, one containing E2F6, and the other containing REST. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. |
| 相似性 | Belongs to the JARID1 histone demethylase family.
Contains 1 ARID domain. Contains 1 JmjC domain. Contains 1 JmjN domain. Contains 2 PHD-type zinc fingers. |
| 功能 | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:50-200} |
| {IF} | {1:100-500} |
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Jarid1C Rabbit pAb, PE conjugated(bs-11000R-PE)-100ul
￥2980
