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SAE1 Rabbit pAb, IRDye 800CW c

onjugated(bs-19364R-IRDye800CW)-100ul
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  • ¥2980
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  • bs-19364R-IRDye800CW
  • 2025年12月01日
  • 产品信息以Bioss网站为准
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    • 规格

      100ul

    产品编号bs-19364R-IRDye800CW
    英文名称SAE1 Rabbit pAb, IRDye 800CW conjugated
    中文名称IRDye 800CW标记的泛素样蛋白SUMO1激活酶抗体
    英文别名Activator of SUMO1; AOS 1; AOS1; FLJ3091; HSPC 140; HSPC140; SAE 1; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS 1; Sentrin/SUMO activating protein AOS1; SUA 1; SUA1; SUMO 1 activating enzyme E1 N subunit; SUMO 1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; SUMO1 activating enzyme E1 N subunit; SUMO1 activating enzyme subunit 1; Ubiquitin like 1 activating enzyme E1A; Ubiquitin like protein SUMO 1 activating enzyme; Ubiquitin like protein SUMO1 activating enzyme; Ubiquitin-like 1-activating enzyme E1A; UBL E1A; UBLE 1A; UBLE1A.
    产品应用WB=1000-10000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SAE1,Isoform 2
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Sumo

    Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ub-like Proteins

    亚基Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds to the two domains that are encoded on a single polypeptide chain in ubiquitin-activating enzyme E1. Interacts with UBE2I.
    亚细胞定位Nucleus.
    组织特异性Expression level increases during S phase and drops in G2 phase (at protein level).
    翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Belongs to the ubiquitin-activating E1 family.
    功能The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
    保存条件Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    背景资料Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

     

    应用推荐稀释比例
    {WB}{1000-10000}

     

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